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'Prevention of Consumption' railway sign, c 1920s.

© National Railway Museum / Science & Society Picture Library -- All rights reserved

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Enamel notice made for the London Brighton & South Coast Railway (LBSCR) reading 'Pasengers are earnestly requested to abstain from the dangerous and objectionable habit of spitting.' Consumption, a wasting disease now known as tuberculosis, was highly infectious. It was not until the development of streptomycin in 1947 that effective and reliable treatment of the disease was posible.
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